This website is intended for people who have been diagnosed with atopic dermatitis (as well as those who know someone with atopic dermatitis).

The JADE Studies
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The JADE studies are designed to assess the safety and effectiveness of an oral investigational drug known as PF-04965842, which is a blocker of an enzyme called Janus kinase. When this enzyme is blocked, the cells of the body’s immune system are expected to produce fewer chemicals believed to cause atopic dermatitis.

To assess PF-04965842, multiple JADE studies are planned. The details of study participation vary with each study. If the study doctor determines that you or your child may be a candidate for one of the studies, the doctor will review details of that study with you and answer any questions before you decide if you or your child should join the study.

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Who can participate?

You may be able to participate in one of the JADE atopic dermatitis studies if you:

  • Are age 12 years or older
  • Weigh at least 40 kilograms (about 88 pounds)
  • Have been diagnosed with chronic moderate to severe atopic dermatitis for at least a year
  • Have a documented recent history (within the last 6 months) of inadequate response to treatment with topical medications
  • Are willing and able to attend study visits and undergo study treatments, tests, and procedures

There are other factors that could determine if you or your child can participate in a JADE study. A study doctor will review other preliminary requirements with you before determining if you or your child may be a candidate to participate in a JADE study. The study doctor will review the study schedule and procedures with you and answer any questions before you decide whether you or your child should join the study. Those who meet preliminary requirements and choose to participate will then have detailed medical assessments with the study doctor to make sure that they meet all requirements for study participation.

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What will happen during the studies?

All JADE study participants will attend scheduled study visits at which they will undergo study procedures, tests, and assessments. These visits will enable the study team to monitor each participant’s health closely throughout the study. The visits will also help researchers and doctors better understand the study treatment’s potential effects on atopic dermatitis and on the body in general. The length of a study visit depends on the number of procedures, tests, and assessments required at the visit.

Participation in a JADE study is completely voluntary. A participant may choose to leave the study at any time, for any reason.

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Participant Responsibilities

All JADE study participants will be responsible for:

  • Following instructions from the study doctor
  • Coming to scheduled study visits
  • Undergoing required study-related procedures, tests, and assessments
  • Reporting any changes in health
  • Keeping their contact information current with the study doctor
  • Understanding the commitment to participating in this study
  • Talking with the study doctor before taking any additional medications (prescription or over-the-counter) or supplements during this study
  • Informing the study doctor of any plans to leave the study

Answering a few questions can help determine if participating in a JADE study may be an option for you or your child.

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